• Alumni

David Thybert

Fellow

Biography.

Contact details:

  • +44 (0) 1603 452 782

david.thybert@earlham.ac.uk

David Thybert received his PhD in computational biology from the University of Rennes (France) in which he performed large scale study of the ROS/RNS detoxification enzymes in procaryote genomes. Following his PhD, he moved to Cambridge to start a postdoc at the EBI. He focused his work on understanding the mechanisms of transcription regulation and genome evolution in mammals using mice as model organisms.

After his postdoc, David was awarded a fellowship at EI where he continues his work on mammals genome evolution and focuses his study on understanding the molecular and evolutionary mechanism of adaptation to environment.

Publications.

The Evolutionary Fates of a Large Segmental Duplication in Mouse.

Morgan AP, Holt JM, McMullan RC, Bell TA, Clayshulte AM, Didion JP, Yadgary L, Thybert D, Odom DT, Flicek P, McMillan L, de Villena FP. Genetics. 2016 Sep;204(1):267-85. doi: 10.1534/genetics.116.191007. Epub 2016 Jul 2.

Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.

Leigh-Brown S, Goncalves A, Thybert D, Stefflova K, Watt S, Flicek P, Brazma A, Marioni JC, Odom DT6. PLoS One. 2015 Sep 4;10(9):e0137367. doi: 10.1371/journal.pone.0137367. eCollection 2015.

Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals.

Wong ES, Thybert D, Schmitt BM, Stefflova K, Odom DT, Flicek P. Genome Res. 2015 Feb;25(2):167-78. doi: 10.1101/gr.177840.114. Epub 2014 Nov 13.

Random monoallelic gene expression increases upon embryonic stem cell differentiation.

Eckersley-Maslin MA, Thybert D, Bergmann JH, Marioni JC, Flicek P, Spector DL. Dev Cell. 2014 Feb 24;28(4):351-65. doi: 10.1016/j.devcel.2014.01.017.

Cooperativity and rapid evolution of cobound transcription factors in closely related mammals.

Stefflova K, Thybert D, Wilson MD, Streeter I, Aleksic J, Karagianni P, Brazma A, Adams DJ, Talianidis I, Marioni JC, Flicek P, Odom DT. Cell. 2013 Aug 1;154(3):530-40. doi: 10.1016/j.cell.2013.07.007.

Latent regulatory potential of human-specific repetitive elements.

Ward MC1, Wilson MD, Barbosa-Morais NL, Schmidt D, Stark R, Pan Q, Schwalie PC, Menon S, Lukk M, Watt S, Thybert D, Kutter C, Kirschner K, Flicek P, Blencowe BJ, Odom DT. Mol Cell. 2013 Jan 24;49(2):262-72. doi: 10.1016/j.molcel.2012.11.013. Epub 2012 Dec 13.

Extensive compensatory cis-trans regulation in the evolution of mouse gene expression.

Goncalves A, Leigh-Brown S, Thybert D, Stefflova K, Turro E, Flicek P, Brazma A, Odom DT, Marioni JC. Genome Res. 2012 Dec;22(12):2376-84. doi: 10.1101/gr.142281.112. Epub 2012 Aug 23.

SORGOdb: Superoxide Reductase Gene Ontology curated DataBase.

Lucchetti-Miganeh C1, Goudenège D, Thybert D, Salbert G, Barloy-Hubler F. BMC Microbiol. 2011 May 16;11:105. doi: 10.1186/1471-2180-11-105.

Multidimensional scaling reveals the main evolutionary pathways of class A G-protein-coupled receptors.

Pelé J, Abdi H, Moreau M, Thybert D, Chabbert M. PLoS One. 2011 Apr 22;6(4):e19094. doi: 10.1371/journal.pone.0019094.

Computer-Assisted Automatic Classifications, Storage, Queries and Functional Assignments of Orthologs and In-Paralogs Proteins.

Thybert, David; Avner, Stephane; Lucchetti-Miganeh, Celine; Barloy-Hubler, Frederique. Current Bioinformatics, Volume 4, Number 2, May 2009, pp. 129-140(12)

OxyGene: an innovative platform for investigating oxidative-response genes in whole prokaryotic genomes.

Thybert D, Avner S, Lucchetti-Miganeh C, Chéron A, Barloy-Hubler F. BMC Genomics. 2008 Dec 31;9:637. doi: 10.1186/1471-2164-9-637.

Related reading.