Research

Automated Nanoscale DNA Assembly

We are working to push the limits of the size and scale of DNA assembly and have recently automated the fabrication of large DNA assemblies in sub-microliter volumes at the Earlham Biofoundry.

The field of bioengineering is underpinned by our ability to assembly bespoke and complex DNA molecules at scale.  We are working to push the limits of the size and scale of DNA assembly and have recently automated the fabrication of large DNA assemblies in sub-microliter volumes at the Earlham Biofoundry. This has been coupled to validation using next-generation sequencing technologies.

Impact statement.

Synthetic biology applies engineering principles such as standardisation and modularisation to biological sciences through application of iterative design-build-test-learn cycles. The standardisation of biological components and reactions allows workflows to be automated. This provides the potential to revolutionise the speed and scale of research, increasing accuracy and allowing miniaturisation to reduce costs. The adoption of these principles and approaches enables scientists to pursue complex experimental designs.

People working on the project.