Postdoctoral Research Scientist (A Hall Group)

Salary range: £33,050 - £40,750
Post no. 1004361
Contract length: 36 Months
Department: Anthony Hall Group
Opening date: 23 November 2022
Closing date: 19 December 2022

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Applications are invited for a Postdoctoral Research Scientist to join the group of Prof Anthony Hall at the Earlham Institute, based in Norwich, UK.

The position is also in collaboration with James Locke’s group at The Sainsbury Laboratory, Cambridge University. The role will fit within a larger cross-institute research programme.

Background:

Earlham Institute is a vibrant research institute with a strong skill base in genomics technologies and bioinformatics. Our vision is to build a future where the biology of any organism can be understood by analysing its genome.

The Hall Group have worked on the plant circadian clock for twenty years and has established an international research profile in this area of work. The candidate will join a multi-disciplinary team from across the institute developing new spatial genomics approaches, at the forefront of cell genomics. They will use these novel approaches to analyse the circadian clock at a cellular resolution.

The Locke group is investigating gene expression dynamics in microbial and plant systems. The group lab is interdisciplinary, combining physics, mathematics, biology and computer science for researchers to understand the design principles of dynamic gene regulation.

The role:

We are looking for a highly motivated Postdoctoral Research Scientist to develop experimental and bioinformatics pipelines that apply a cutting-edge spatial transcriptomics approach to investigate functional clock architecture at a single-cell resolution in Arabidopsis and wheat. This exciting project will use the plant circadian clock as a model to investigate the interplay of complex regulatory networks across multiple cell types and determine how cell state affects the clock.

Duties will specifically include:

  • Working collaboratively across the Earlham Institute to develop spatial transcriptomic protocols for both Arabidopsis and wheat for analysing the circadian clock; specifically with Iain Macaulay’s single-cell group.
  • Collaborate with Plant Cell Atlas.
  • Analyse complex transcriptional datasets and collaborate with the Locke group to develop mathematical models.
  • Using comparative approaches to investigate differences in circadian clock function between species.
  • Work in collaboration with the Earlham Biofoundry to generate DAP-seq datasets to identify DNA targets for clock transcription factors and other critical regulatory transcriptional networks in wheat.
  • In addition to this, the post holder will have the opportunity to co-supervise PhD students within the group.

The ideal candidate:

Applicants should possess a PhD in a biological science with experience in molecular biology, single-cell biology, or circadian biology. We are also looking for candidates with experience in applying computation biology and bioinformatic approaches during their research.

The post holder will be a team player with a broad knowledge of plant molecular biology, plant genetics, basic statistics, and coding (e.g., expertise in R or python). Experience working with large datasets and collaborating with other research groups across interdisciplinary research projects would be advantageous, as well as experience working in an HPC environment.

Additional information:

  • Salary on appointment will be within the range £33,050 to £40,750 per annum depending on qualifications and experience.  This is a full-time post for a contract of 36 months.
  • Interviews will be held on either 5 or 6 January 2023.
  • As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.
  • The closing date for applications will be 19th December 2022.