Postdoctoral Research Scientist (Novel statistics and bioinformatics for microbiome analysis)
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Applications are invited for a Postdoctoral Research Scientist to join the Laboratory of Dr Quince in the High-Resolution Microbiomics group at the Earlham Institute, based in Norwich, UK.
The group uniquely focusses on both theoretical and experimental methods for microbial community analysis. Combining statistical bioinformatics with technological developments in sequencing and ‘omics data generation to resolve both the microbes present in a community and their functional roles and interactions.
The aim will be to improve methods for de novo strain level analysis from metagenome data. Potential areas of research include Bayesian reconstruction of strain-level genomes from metagenomes and the development of predictive mechanistic microbial community models through the integration of other 'omics data. To address these problems the individual will be expected to apply methods from Bayesian statistics and machine learning. The development of predictive models may incorporate aspects of dynamical systems in addition to metabolic modelling.
These new tools will be applied to a variety of microbiome data sets studied in the group including coupled metagenome metabolome samples to understand the role of therapeutic diets in the treatment of Crohn’s disease, the transmission of AMR through the human and murine gut and the phyllosphere microbiome.
The ideal candidate:
The ideal candidate will have PhD in bioinformatics or statistics, or a related subject area with strong element of statistical modelling. They will also have a First-class degree in any area of science.
Knowledge of command line bioinformatics, software programming in at least one language (e.g. R, Python, C/C++) and a basic understanding of statistics are essential requirements for this role.
A proven record in scientific writing with experience of oral research presentations are also essential.
Knowledge of Bayesian statistics and probabilistic modelling, bioinformatics of metagenomics or metabolomics and a biological understanding of microbial communities and metabolism would be advantageous.
- Salary on appointment will be within the range £33,050 to £40,750 per annum depending on qualifications and experience. This is a full-time post for a contract of 36 months.
- Interviews will be held on 18th November 2022.
- As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.
- The closing date for applications will be 3 November 2022.