• Research

Mark McMullan

Population Genomicist

Biography.

Contact details:

  • +44 (0) 1603 450 068

mark.mcmullan@earlham.ac.uk

@mcmullan0

ORCHID iD

Presently, at EI, Mark works on the population genomics of the Ash Dieback pathogen, combining both bioinformatics and population biology to understand the processes that underlie the invasion and spread of this pathogen across Europe.

Mark is also using the recent domestication of sugar beet (Beta vulgaris) from sea beet (subs. maritima) to understand the role of wild hosts as pathogen reservoirs for agricultural invasion.

Prior to this Mark worked on an ERC funded project with Jonathan Jones at The Sainsbury Laboratory (TSL) where he contributed to the population genomic analyses of Albugo candida and A. laibachii. This post at TSL began directly after an ELSA funded Senior Research Associate position (University of East Anglia) where he was involved in the population genetics/genomics of four other systems including Antarctic diatoms (Thomas Mock), Arabidopsis thaliana (Caroline Dean), Primula species (Phil Gilmartin) and guppies (Cock van Oosterhout).

The overarching focus of Mark's projects continues to be to apply population genetic approaches to genomes to better understand adaptive evolution. He maintains a special focus on the relative contribution of the five-evolutionary forces and the role of hybridisation and introgression to host-pathogen co-evolution.

Mark also contributes to the UEA Molecular Plant-Microbe Interactions module as a guest lecturer. To find out more about Mark's research, read his blog post on Sex Between Crop Pathogens.

Publications.

Evolutionary genomics of the cold-adapted diatom Fragilariopsis cylindrus

T Mock, RP Otillar, J Strauss, M McMullan, P Paajanen, J Schmutz, ...
Nature, 1-5, 2017

The effects of recombination, mutation and selection on the evolution of the Rp1 resistance genes in grasses

A Jouet, M McMullan, C Oosterhout
Molecular ecology 24 (12), 3077-3092, 2015

Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite

M McMullan, A Gardiner, K Bailey, E Kemen, BJ Ward, V Cevik, ...
Elife 4, e04550, 2015

Divergent selection for opsin gene variation in guppy (Poecilia reticulata) populations of Trinidad and Tobago

A Tezuka, S Kasagi, C Van Oosterhout, M McMullan, WM Iwasaki, ...
Heredity 113 (5), 381-389, 2014

Multiple FLC haplotypes defined by independent cis-regulatory variation underpin life history diversity in Arabidopsis thaliana

P Li, D Filiault, MS Box, E Kerdaffrec, C van Oosterhout, AM Wilczek, ...
Genes & Development 28 (15), 1635-1640, 2014

Ultra‐deep Illumina sequencing accurately identifies MHC class IIb alleles and provides evidence for copy number variation in the guppy (Poecilia reticulata)

J Lighten, C Oosterhout, IG Paterson, M McMullan, P Bentzen
Molecular ecology resources 14 (4), 753-767, 2014

Can parasites use predators to spread between primary hosts?

J Cable, GA Archard, RS Mohammed, M Mcmullan, JF Stephenson, ...
Parasitology 140 (09), 1138-1143, 2013

Parasites pitched against nature: Pitch Lake water protects guppies (Poecilia reticulata) from microbial and gyrodactylid infections

B Schelkle, RS Mohammed, MP Coogan, M McMULLAN, EL Gillingham, ...
Parasitology 139 (13), 1772, 2012

Upstream guppies (Poecilia reticulata, Peters, 1859) go against the flow

RS Mohammed, C van Oosterhout, B Schelkle, J Cable, M McMullan
Biota Neotropica 12 (3), 68-72, 2012

Inference of selection based on temporal genetic differentiation in the study of highly polymorphic multigene families

M McMullan, C Van Oosterhout
PloS one 7 (8), e42119, 2012

Cryptic MHC polymorphism revealed but not explained by selection on the class IIB peptide-binding region

V Llaurens, M McMullan, C Van Oosterhout
Molecular biology and evolution, mss012, 2012

Evolutionary genetics and molecular ecology of the Major Histocompatibility Complex (MHC) genes of poeciliids

M McMullan, C Van Oosterhout
Chicago University Press, 2011

Colour Variation of an Individual of Hart's Rivulus (Rivulus hartii) found in a Habitat Rich in Polycyclic Aromatic Hydrocarbons in the Pitch Lake of Trinidad

RS Mohammed, MJ McMullan, B Schelkle, C Van Oosterhout
Ecologia Balkanica 2, 2010

Solutions for PCR, cloning and sequencing errors in population genetic analysis

SM Cummings, M McMullan, DA Joyce, C Van Oosterhout
Conservation genetics 11 (3), 1095-1097, 2010

Host-parasite co-evolution and genetic variation at the Major Histocompatibility Complex in the Trinidadian guppy (Poecilia reticulata)

M McMullan
University of Hull, 2010

Selection by parasites in spate conditions in wild Trinidadian guppies (Poecilia reticulata)

C van Oosterhout, RS Mohammed, H Hansen, GA Archard, M McMullan, ...
International journal for parasitology 37 (7), 805-812, 2007