How are we related? A Compara-bly easy workflow to find gene families
26 February 2018
We release ‘GeneSeqToFamily’, an open-source Galaxy workflow that helps scientists to find gene families.
Published in Gigascience, the open source Galaxy workflow allows researchers to make easier work of finding gene families; an important tool when it comes to analysing the evolution, structure and function of genes across species.
Co-author Wilfried Haerty, Group Leader of Evolutionary Genomics at EI, explained why this tool is so useful to biologists: “The software developed at the Earlham Institute enables scientists to investigate species of interest using a flexible and reproducible pipeline. The performance of our workflow was assessed on vertebrate genome assemblies of various qualities (platypus, pig, horse, dog, mouse and human). The species were selected to assess the impact of genome quality on gene families identification. The mouse, dog and human genomes are of high quality whereas the three others are at different stages of analysis completion.”
Importantly, the workflow is highly customisable, allowing users to choose parameters, change tools and run the software on their own genes, without having to use the Ensembl database.
Not just a workflow, GeneSeqToFamily contains a number of new, standalone Galaxy tools, including TreeBeST, hcluster_sg, T-Coffee and ETE. Developed at EI by Anil
The team hopes that the new workflow will help users unfamiliar with the complexities associated with using
Earlham Institute is committed to providing tools and algorithms to support, enable and develop computational biology and life sciences research, with projects such as Galaxy helping to open access to a range of scientific tools and databases.
The Data Infrastructure Group, led by Dr Rob Davey, also supports resources such as
Notes to editors
For more information, please contact:
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The Earlham Institute (EI) is a world-leading research institute focusing on the development of genomics and computational biology. EI is based within the Norwich Research Park and is one of eight institutes that receive strategic funding from Biotechnology and Biological Science Research Council (BBSRC) - £6.45M in 2015/2016 - as well as support from other research funders. EI operates a National Capability to promote the application of genomics and bioinformatics to advance bioscience research and innovation.
EI offers a state of the art DNA sequencing facility, unique by its operation of multiple complementary technologies for data generation. The Institute is a UK hub for innovative bioinformatics through research, analysis and interpretation of multiple, complex data sets. It hosts one of the largest computing hardware facilities dedicated to life science research in Europe. It is also actively involved in developing novel platforms to provide access to computational tools and processing capacity for multiple academic and industrial users and promoting applications of computational Bioscience. Additionally, the Institute offers a training programme through courses and workshops, and an outreach programme targeting key stakeholders, and wider public audiences through dialogue and science communication activities.
The Biotechnology and Biological Sciences Research Council (BBSRC) invests in world-class bioscience research and training on behalf of the UK public. Our aim is to further scientific knowledge, to promote economic growth, wealth and job creation and to improve quality of life in the UK and beyond.
Funded by Government, BBSRC invested over £509M in world-class bioscience in 2014-15 and is the leading funder of wheat research in the UK (over £100M investment on UK wheat research in the last 10 years). We support research and training in universities and strategically funded institutes. BBSRC research and the people we fund are helping society to meet major challenges, including food security, green energy and healthier, longer lives. Our investments underpin important UK economic sectors, such as farming, food, industrial biotechnology and pharmaceuticals.