• Research

Edyta Wojtowicz

Postdoctoral Scientist

Biography.

Contact details:

  • +44 1603 450 871

edyta.wojtowicz@earlham.ac.uk

Edyta Wojtowicz

Edyta is a Sir Henry Wellcome Postdoctoral Fellow in Dr Macaulay’s group. She is a molecular haematologist with a particular interest in platelet biology. Platelets are small but important blood cells: they stop bleeding at sites of injury, and counter infections by providing a physical barrier to the outside world. Their studies have been hampered by lacking methods and only recently gained more attention. Her research project aims to improve our understanding of cells normally producing platelets, with the goal to increase platelet production.

After a completion of MSc in Medical Biotechnology at the Jagiellonian University, Krakow Edyta did a PhD in Molecular Medicine at the University Medical Centre/Rijksuniversiteit Groningen as a Marie Curie Early Stage Researcher. During her PhD she worked together with Prof. Gerald de Haan and Dr. Leonid Bystrykh on the project focused on cellular and molecular characterization of miR-125 family in normal and malignant haematopoiesis.

Subsequently, she was a Barncancerfonden Postdoctoral Fellow working with Prof. Sten Eirik Jacobsen at Karolinska Institutet, performing quantitative clonal studies of unperturbed haematopoiesis using a newly developed approach enabling entirely in vivo barcoding of haematopoietic stem cells.

Publications.

MiR-125a enhances self-renewal, lifespan, and migration of murine hematopoietic stem and progenitor cell clones

Wojtowicz EE, Broekhuis MJ, Weersing E, Dinitzen A, Vervskaya E, Ausema A, Ritsema M, Zwart E, de Haan G, Bystrykh LV (2019) Scientific Reports 9:4785

Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors

Wojtowicz EE, Lechamn ER, Hermans KG, Schoof EM, Wienholds E, Isserlin R, van Veelen PA, Broekhuis MJ, Janssen GM, Trotman-Grant A, Dobson SM, Elzinga J, Kennedy J, Gan OI, Sinha A, Ignatchenko V, Kislinger T, Dethmers-Ausema B, Weersing E, Alemdehy MF, de Looper HW, Bader GD, Ritsema M, Erkeland SJ, Bystrykh LV, Dick JE, de Haan G (2016) Cell Stem Cell 19(3):383-96

MicroRNA-125 family members exert a similar role in the regulation of murine hematopoiesis

Wojtowicz EE, Walasek MA, Broekhuis MJ, Weersing E, Ritsema M, Ausema A, Bystrykh LV, de Haan G (2014) Exp. Hematol. 42(10):909-18

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation, hyperactivation and cause inflammation and autoimmunity in aged mice

Chu Y, Vahl JC, Kumar D, Heger K, Bertossi A, Wojtowicz E, Soberon V, Schenten D, Mack B, Reutelshöfer M, Beyaert R, Amann K, van Loo G, Schmidt-Supprian M (2011) Blood 117:2227-2236

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

Wojtowicz EE, Verovskaya E, de Haan G (2015) Springer book chapter: Aging of Murine Hematopoietic Stem Cells (pp107-125)

microRNAs in hematopoiesis

Lazare SS, Wojtowicz EE, Bystrykh LV, de Haan G (2014) Experimental Cell Research 329(2):234-238