The taming of the <del>shrew</del> dog, cow, horse, pig and rabbit.
Research at the Earlham Institute into one of the “genetic orchestra conductors”, microRNAs, sheds light on our selectively guided evolution of domestic pets and farmyard animals such as dogs and cows.
What does a cow, a horse, a pig, a rabbit and a dog have in common, and how similar or dissimilar are their genetic conductors?
They’re all animals domesticated by humans - and the results have been quite incredible. Over just a few thousand years of selective breeding, these creatures have been bred for specific characteristics, leading to an incredible morphological and behavioral variety across breeds . Better understanding of the domestication process can lead to better, more sustainable food and a greater understanding of human diseases.
Dr Luca Penso-Dolfin at Earlham Institute has been looking at these species’ brains, testicles, hearts and kidneys for clues into how microRNAs (miRNAs), important regulators of cell development in mammals, differ across all of these tissues, and how this might affect the evolution of gene regulation.
The research is published in Nature’s open access journal Scientific Reports, titled: “The evolutionary dynamics of miRNA in domestic mammals”.
It turns out that brains and testes were particularly abundant in recently evolved “new” miRNAs, some of which might be linked to important domestication genes in dogs and cows. Perhaps this is one of the drivers behind the fascinating diversity in dog breeds that we have produced?
Dr Luca Penso-Dolfin told us, “The evolution of different miRNAs in different species might lead to important changes in how genes are used and controlled. These modifications, which might happen both in space (different tissues) and time (for example, different developmental stages) are still not fully understood. Further research is needed to better clarify the role of miRNAs in the evolution of mammalian gene regulation.”
miRNAs are essentially one of the main reasons why, even though the DNA of every cell in an individual (give or take a few) is the same, we are able to produce 200 different types of cell in a human body. If DNA is an orchestra, miRNA is the conductor. Sometimes we don’t need the violin to be constantly playing and occasionally the oboe needs to be muted.
By comparing the five domestic animals in the study to a database of miRNAs, Dr Penso-Dolfin was able to identify which miRNAs were “old” miRNAs, present across many mammal species, and which miRNAs had evolved more recently, in only one or a few species. These “new” miRNAs were found to be more specific to certain tissues, with most found in the brain and the testes.
From the perspective of evolution, it looks like these “new” miRNAs have an important role to play in the emergence of novel traits, especially when looking at cows and dogs, and analysis of the genes that the miRNAs work on suggests that their gene targets are enriched for genes under artificial selection - so it appears that the team have found some miRNAs that are of importance to the domestication process.
Domestic mammals are of great economic and biomedical interest. A better understanding of gene regulation in these species might help us to shed light on some diseases common to ourselves. The diseases presenting in dogs, for example, have many commonalities with those in humans. The pig’s high resemblance to human anatomy is of further interest. Moreover, some of these species (especially the cow and the pig) represent an important food source, meaning that the same discoveries might also be relevant for milk production, meat quality, and resistance to disease or stress.
Professor Federica Di Palma, former Director of Science at EI, said, “the study of small regulatory RNAs as crucial regulators of diverse biological processes is an exciting area of research that continues to open up new avenues to explore when it comes to unravelling the complex evolution of economically important traits. Understanding the roles of miRNAs and their co-evolution with target genes in domestication can help not only improve understanding of fundamental biological processes but will also help us to better understand key traits of domestication selection with important applications to food security.”
We’re not so different from the mammals we live in such close proximity to, therefore the better we understand how they develop, the more light we can shed on our own evolution - and perhaps answer many difficult questions on how to cure certain diseases.
The team now plans to scale the research up to compare domestic mammals with wild animals, to get an even greater understanding of the important mechanisms underpinning how we’ve managed to produce such a range of domesticated species with specialist characteristics.
Notes to editors.
Notes to editors
For more information, please contact:
Marketing & Communications Officer, Earlham Institute (EI)
- +44 (0)1603 450 107
About Earlham Institute
The Earlham Institute (EI) is a world-leading research Institute focusing on the development of genomics and computational biology. EI is based within the Norwich Research Park and is one of eight institutes that receive strategic funding from Biotechnology and Biological Science Research Council (BBSRC) - £5.43m in 2017/18 - as well as support from other research funders. EI operates a National Capability to promote the application of genomics and bioinformatics to advance bioscience research and innovation.
EI offers a state of the art DNA sequencing facility, unique by its operation of multiple complementary technologies for data generation. The Institute is a UK hub for innovative bioinformatics through research, analysis and interpretation of multiple, complex data sets. It hosts one of the largest computing hardware facilities dedicated to life science research in Europe. It is also actively involved in developing novel platforms to provide access to computational tools and processing capacity for multiple academic and industrial users and promoting applications of computational Bioscience. Additionally, the Institute offers a training programme through courses and workshops, and an outreach programme targeting key stakeholders, and wider public audiences through dialogue and science communication activities.