
Biography
Contact details:
I am an undergraduate student studying Biological Sciences at Durham University, currently here at EI as a year in industry student. During this year, I hope to discover more about genomics, an interest that was sparked during my first two years of my degree. I hope to use the year to expand my knowledge in the field and apply the theories and techniques I have learned previously to my own research project.
My year in industry project is a collaboration between multiple faculty groups: the Macaulay, Haerty and Swarbreck groups and Genomic Pipelines. Over the past decade, significant advances have been made in single-cell RNA sequencing. Smart-seq3 is a new single-cell RNA sequencing protocol published by Hagemann-Jenson et al., 2020; I will be working to establish a Smart-seq3 pipeline within EI. This will involve performing a comparison between Smart-seq3 and Smart-seq2 (the current protocol used), for their use in single-cell analysis of human cancer cell lines to assess gene expression heterogeneity.
I will then work towards building a 384-well plate Smart-seq3 pipeline, which could potentially enable parallel sequencing of up to 1,536 cells in a single experiment. During my project I will gain experience in cell sorting, method development, laboratory automation, next generation sequencing and the associated bioinformatic skills to enable me to analyse my own sequencing data.
Related reading.

Finding fungi at the fen

The genetic machinery that drives biodiversity

On the origin of errors: the causes and consequences of mistakes during DNA replication

Could long-read RNA sequencing be the future of drug discovery?

Why is genome annotation important?

Why cloud computing is important for data-driven bioscience research

How bioinformatics can crack the complex case of protist biodiversity

The dramatic effects genomics will have on our future world

Exotic wheat DNA could help breed ‘climate-proof’ crops

Sequencing project to unleash the huge potential of euglenoids

Circadian clock insights could be key to increased wheat yields

European consortium launched to reverse biodiversity loss through genomics research

Tracking bacterial evolution in real time spots emergence of antimicrobial resistance

Big Data initiative awarded £6.3 million as part of major UKRI investment in research infrastructure

Not all looks rosy for the pink pigeon

Coronavirus jams communication signals to immune cells in the gut
