Single-cell sequencing at Earlham Institute
Developing and applying new technology to decode life at single-cell level.
Biography
I am a Norwich Biosciences Doctoral Training Partnership PhD student working in the Macaulay group, that focusses on technical development and application of new approaches for integrated sequencing of single-cells. More specifically, my research project focusses on unravelling the complexity of alternative splicing in hematopoietic stem cells - to understand how cells regulate the expression of individual isoforms as part of their functional heterogeneity using cutting-edge techniques in single-cell genomics.
Prior to my research at the Earlham Institute, I completed my BSc (Hons) Molecular Biology and Genetics and MSc (Hons) Molecular Medicine degrees at the University of East Anglia, Norwich. During my MSc research project at the John Innes Centre, I specialised in CRISPR/Cas9 site-directed mutagenesis in yeast to investigate fungicide resistance. After being exposed to the ground-breaking research taking place within the Norwich Research Park, I was thrilled to be offered a PhD position at the Earlham Institute and be part of this vibrant research community.
Related reading.
Image
27 January 2023
People
Science
FEATURE
| 5 min READ
Excellent science? It’s in the technical detail
While a lot of people might still picture scientific breakthroughs as down to a lone genius having a eureka moment, science is a team sport.
Image
20 December 2022
Science
Public engagement
FEATURE
| 3 min READ
Finding fungi at the fen
The Earlham Institute and Royal Botanic Gardens, Kew received funding from Wellcome to train the Norfolk Fungus Study Group (NFSG) in sampling fungi for the Darwin Tree of Life (DToL) project, which aims to sequence the genome of every eukaryotic organism in Britain and Ireland.
Image
01 July 2022
Science
FEATURE
The genetic machinery that drives biodiversity
Thanks to new technologies and novel approaches to big data, researchers are revealing new secrets into the genetic processes that power Cichlid evolution.
Image
23 March 2022
Science
FEATURE
On the origin of errors: the causes and consequences of mistakes during DNA replication
DNA replication is a simple enough concept. Copy, divide, rest, repeat. While the basic idea is straightforward, the actual machinery governing the process of replication remains something of an enigma.
Image
22 February 2022
Science
FEATURE
| 8 min READ
Could long-read RNA sequencing be the future of drug discovery?
New research using long-read RNA sequencing provides a robust platform for the future discovery of novel gene isoforms and future medicines.
Image
11 February 2022
Science
FEATURE
| 10 min READ
Why is genome annotation important?
Genome annotation is no simple feat, but it’s incredibly important in identifying the functional elements of DNA. Building the appropriate tools and pipelines is key.
Image
04 February 2022
Science
Technology
FEATURE
| 5 min READ
Why cloud computing is important for data-driven bioscience research
Access to powerful compute resources via our cloud computing infrastructure enables bioscience research, collaboration, and innovation.
Image
10 December 2021
Science
FEATURE
| 15 min READ
How bioinformatics can crack the complex case of protist biodiversity
Protists defy taxonomic classification and wow us with their weirdness on a daily basis. They’ve been excruciatingly difficult to study but, thanks to single-cell genomics and bioinformatics being carried out at the Earlham Institute, we’re finally decoding their abundant biodiversity.
Image
25 November 2021
Science
FEATURE
| 8 min READ
The dramatic effects genomics will have on our future world
Fish and chips, fabrics, personalised medicine and coffee. These are just some of the things you might have Earlham Institute researchers to thank for in the decades to come.
10 January 2023
Image
Exotic wheat DNA could help breed ‘climate-proof’ crops
Wheat containing exotic DNA from wild relatives benefits from up to 50 per cent higher yields in hot weather compared with elite lines lacking these genes.
22 November 2022
Image
Sequencing project to unleash the huge potential of euglenoids
An ambitious plan to sequence the genomes of all known species of euglenoids over the next decade has been launched today.
24 October 2022
Image
Circadian clock insights could be key to increased wheat yields
New research carefully measuring the influence and regulation of the circadian clock in wheat could help breeders improve key agricultural traits in one of the world’s most important crops.
28 September 2022
Image
European consortium launched to reverse biodiversity loss through genomics research
A quantum leap in the use of genomics is needed to reverse unprecedented species loss and ecosystem degradation, according to a new pan-European consortium of leading research organisations.
22 September 2022
Image
Tracking bacterial evolution in real time spots emergence of antimicrobial resistance
Single-cell genomics technology could transform understanding of how bacterial populations evolve and combat the growing issue of antibiotic resistance
29 June 2022
Image
Big Data initiative awarded £6.3 million as part of major UKRI investment in research infrastructure
UK Research and Innovation has awarded £6.3 million of new funding to support the development of BioFAIR, a collaborative virtual infrastructure that will support the sharing and management of life science data.
13 May 2022
Image
Not all looks rosy for the pink pigeon
Boosting numbers of the once critically endangered pink pigeon may not be enough to save it from extinction in the future, according to a major study on the iconic species.
02 May 2022
Image
Coronavirus jams communication signals to immune cells in the gut
A computer model could help to reveal how some infectious diseases - including COVID-19 - trigger an overactive immune response in certain patients, which can drive inflammation and lead to serious complications or even death.
28 April 2022
Image
Precision medicine tool finds hidden genetic connections that could personalise IBD treatment
People with Inflammatory Bowel Disease (IBD) develop the condition due to distinct and different mechanisms, determined by their genetics. Researchers and clinicians from the Quadram Institute, the Earlham Institute, the Norfolk and Norwich University Hospital and University of East Anglia with collaborators in Cambridge, London and Leuven (Belgium), have found that natural genetic variation appears to influence the development of IBD.