Research

Jose A. Carrasco Lopez

BIO Foundry Manager

Patron Group

Biography.

Contact details:

+44 (0) 1603 450 897

jose.carrasco-lopez@earlham.ac.uk

Jose A. Carrasco Lopez

Jose A. Carrasco Lopez is the manager of the Earlham BIO Foundry. The BIO Foundry provides the UK bioscience community access to automated platforms for nano-scale modular DNA assembly, verification and delivery to plant and microbial cells. It is also able to serve as a repository for large collections of DNA parts.

Jose is a microbiologist and molecular biologist interested in pursuing biotech innovation and new approaches to solve human problems.

Jose obtained his PhD in Cellular and Molecular Biology studying the interaction of rhizosphere’s bacteria and legumes as a new tool for heavy metal bioremediation. In post-doctoral research at University of Maryland, Baltimore, USA, he first studied (at Patrik Bavoil lab) the role of the pmp gene family in Chlamydia trachomatis pathogenesis and, later on (at James Galen lab, CVD), developed attenuated Salmonella enterica serovars as live vector vaccine strains.

His experience includes more than 15 years working in the Microbiology, Molecular Biology and Biotechnology fields, studying host/pathogen interactions, human pathogens, developing vaccines and working with bacteria of industrial interest.

Projects.

Automated Nanoscale DNA Assembly

Publications.

Building a global alliance of biofoundries.

May 2019

Hillson N., Caddick M., Cai Y., Carrasco J. A., Chang M. W., Curach N. C., Bell D. J., Le Feuvre R., Friedman D. C., Fu X., Gold N. D., Herrgård M. J., Holowko M. B., Johnson J. R., Johnson R. A., Keasling J. D., Kitney R. I., Kondo A., Liu C., Martin V. J. J., Menolascina F., Ogino C., Patron N. J., Pavan M., Poh C. L., Pretorius I. S., Rosser S. J., Scrutton N. S., Storch M., Tekotte H., Travnik E., Vickers C. E., Yew W. S., Yuan Y., Zhao H., Freemont P. S.

Building a global alliance of biofoundries.

Nature communications

Publishers version: doi:10.1038/s41467-019-10079-2

Expression of genes involved in metabolism of phenolic compounds by Lactobacillus pentosus and its relevance for table-olive fermentations.

Dec 2018

Carrasco Lopez J., Lucena-Padrós H., Brenes M., Ruiz-Barba J. L.

Expression of genes involved in metabolism of phenolic compounds by Lactobacillus pentosus and its relevance for table-olive fermentations.

Food Microbiology

Publishers version: doi:10.1016/j.fm.2018.06.020

Aug 2020

Cai Y,Carrasco Lopez J,Patron NJ

Phytobricks: Manual and automated assembly of constructs for engineering plants

Publishers version: doi:10.1007/978-1-0716-0908-8_11

A biofoundry workflow for the identification of genetic determinants of microbial growth inhibition.

Jan 2021

Moffat AD,Elliston A,Patron NJ,Truman AW,Lopez JAC

A biofoundry workflow for the identification of genetic determinants of microbial growth inhibition.

Synthetic Biology

Publishers version: doi:10.1093/synbio/ysab004

A Bivalent Typhoid Live Vector Vaccine Expressing both Chromosome- and Plasmid-Encoded Yersinia pestis Antigens Fully Protects against Murine Lethal Pulmonary Plague Infection

James E. Galena, Jin Yuan Wanga, Jose A. Carrascoa, Scott A. Lloyda, Gabriela Mellado-Sancheza, Jovita Diaz-McNaira, Olga Francoa, Amanda D. Buskirka, James P. Nataroa and Marcela F. Pasettia