Combatting wheat take-all disease with in-field and synthetic microbial communities

Vacancy details:

Start date: 01 October 2026
Application deadline: 02 December 2025
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The rhizosphere – the region of soil and associated microbes directly interacting with plant roots - is an area that is increasingly recognised for its role in plant health.

This is particularly relevant for take-all, the most devastating wheat root disease worldwide, which can reduce yields by up to 20%.

The importance of root microbial community in take-all symptom prevention is well established, as both bacterial and fungal species have been found which suppress take-all development.

Understanding genome regulation in Miscanthus hybrids for sustainable bioenergy

Vacancy details:

Start date: 01 October 2026
Application deadline: 02 December 2025
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This project aims to determine how hybridisation and polyploidisation independently and jointly shape transcriptional evolution in Miscanthus hybrids, and to investigate how regulatory, epigenetic, and structural mechanisms contribute to the balance or dominance among subgenomes.

Exploring niche cell–cell communication through alternative splicing

Vacancy details:

Start date: 01 October 2026
Application deadline: 02 December 2025
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Cells in the body constantly send and receive messages to coordinate development, maintain health, and respond to disease. Many of these messages are passed through cell surface proteins - receptors and ligands - that allow cells to “talk” to one another.

Recent research shows that the instructions for building these proteins can be edited by cells in real-time through a process called alternative splicing, resulting in different versions (or isoforms) of the same protein with very different functions.

Exploring the influence of obesity on immune response

Vacancy details:

Start date: 01 October 2026
Application deadline: 02 December 2025
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Platelets are increasingly recognised as key regulators of immune responses, extending their function far beyond their traditional role in blood clotting. 

This project will investigate how a high-fat diet and obesity impact megakaryocyte function and platelet production, and how these changes impair the immune response to infection. 

John Innes Foundation Rotation PhD Programme

Vacancy details:

Start date: 01 October 2026
Application deadline: 13 November 2025
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Four-year multidisciplinary PhD opportunities in genetics, genomics, cell biology, microbiology, molecular biology, crop science, biological chemistry, applied mathematics, computational and systems biology.

The programme involves the John Innes Centre, Earlham Institute and The Sainsbury Laboratory, three internationally recognised centres of excellence in plant, microbial and data sciences, based in Norwich, UK.

Research

Edward Holtom

Year in Industry Student
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Biography

Personal Pronouns: He/him

Contact details:

edward.holtom@earlham.ac.uk

Edward Holtom

I am a 3rd year undergraduate biology student from the University of York, currently undertaking a Year in Industry in the Haerty lab. 

My research this year investigates the functional implications of alternative splicing across different cell lineages. This involves utilising computational and laboratory techniques in the Earlham Biofoundry to characterise the co-regulation of isoforms involved in the formation of functional protein complexes.

My interests lie in the intersection of synthetic biology, molecular genetics and plant pathology, with a focus on the application of these fields for environmental and societal welfare. These interests were fostered by my time at the Gatsby Plant Science Summer School 2024, after which I completed a summer project at Imperial College London in 2025, funded by the British Society for Plant Pathology. 

While in London, I conducted computational and laboratory research into the roles and networks of a family of intracellular immune receptors in broad bean, a novel plant system.

Looking into the future, I aim to pursue a career in research, collaborating with the global scientific community to contribute to the development of sustainable solutions to global challenges.

Research

Poppy Leslie

Year in Industry Student
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Biography

Personal Pronouns: She/her

Contact details:

  • +44 1603 450 263

poppy.leslie@earlham.ac.uk

Poppy Leslie

 


 

I am a year in industry student from the University of York working within Neil Hall’s Group. Supervised by Rowena Hill and Mark McMullan, my project aims to explore the evolution of lifestyle within the fungal lineage Gaeumannomyces, a genus including pathogens such as Gaeumannomyces tritici (causing wheat take-all disease) and other less characterised mutualistic and antagonistic species. 

Using phylogenetic analysis, comparative genomics and pathogenicity tests, I am interested in exploring the phylogeny of Gaeumannomyces, calculating divergence time estimation and looking for genomic regions that may underpin different lifestyles.

Prior to this year, I attended Gatsby Plant Science Summer School and completed an internship at the environmental organisation 'How the Earth Thinks' where I developed an interest in the rhizosphere, plant-fungal interactions and sustainable agriculture.

Additionally, I am part of the Youth Panel for the British Dragonfly Society where I enjoy attending field trips, science communication and helping young people feel represented within nature conservation.

Helping the world transition to sustainable agriculture

08 October 2025

For the first time, four major multi-national companies - BASF, Bayer, Corteva and Syngenta - visited the Norwich Research Park to discuss the urgent need to develop solutions for sustainable agriculture.

Notes to editors.

Research

Will Shaw

Career Development Fellow
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Biography

Contact details:

will.shaw@earlham.ac.uk

@willshaw.bsky.social

ORCiD
 

Will is a synthetic biologist with expertise in yeast and plant engineering. His research focuses on developing technologies to accelerate plant genetic engineering and functional studies.

Will earned his PhD at Imperial College London with Prof. Tom Ellis, where he pioneered new genome engineering approaches to study yeast signalling pathways. Building on this foundational work, he then expanded into biosensing and synthetic multicellularity.

Supported by an EMBO Fellowship, Will carried out postdoctoral research at Boston University with Prof. Mo Khalil and Prof. Mary Gehring (MIT), where he transitioned into plant synthetic biology, developing new methods and technologies for precision plant transgenesis and genome editing.

At the Earlham Institute, under the mentorship of Dr Conrad Nieduszynski, his work focuses on rewriting plant chromosomes to decode genome function, with the long-term goal of engineering more resilient and productive crops.