Day in the Life of … a genomic investigator and Jiu Jitsu master
Ever wondered what our scientists are getting up to inside EI? Our Day in the Life of series delves into the researchers’ daily lives of decoding living systems.
We start with Post Doctoral scientist Ross Low in the Hall Group, who we speak to about seeking out global antimicrobial resistance to fight disease by investigating genome evolution, how ‘gut-interplay’ is on his study bucket list and Japanese martial arts helps him unwind.
How did you get into genomics, why did you choose EI?
My interest in genomics started during my undergraduate degree in Biochemistry. Genomes come in all shapes and sizes but at the end of the day it all comes down to A’s T’s C’s and G’s (and occasionally U’s). It’s also an exciting field of research with new sequencing technologies and analysis programmes emerging all the time.
Goliaths like the Human Genome Project have paved the way for genomics to be a powerful tool for many labs. As soon as genome sequencing becomes available on the NHS, they’ll need all the bioinformaticians they can get. I came to EI because it is a
Can you tell us about your role at EI? What’s your motivation?
My role revolves loosely around evolutionary genomics, but that’s a pretty broad term. I’m a postdoc and I mainly work on
I work a lot with intestinal organisms that are linked to
What does your typical day look like?
My typical day entails mostly working at my computer, albeit a really nice computer and a comfy chair; so it’s not so bad, with brief breaks for sustenance. Kidding aside, the nature of my work means that no two days are exactly alike. As each project progresses, I am able to follow it on to the next stage of analysis.
Having multiple projects on the go is also a bonus which helps to keep things interesting. For example, I have just finished the ‘assembly phase’ of a project whereby I was attempting to
... don’t try to annotate a genome manually, trust me, it’s not worth it.
What project are you currently working on?
My main project is working on the analysis of 10,000 Salmonella genomes from around the world. The project takes a global approach to understanding the epidemiology, transmission
The genomes have been collected from 52 countries around the world and I’m working on searching through these to find clues about what bestows antimicrobial resistance (AMR) on a particular group of stains, what differentiates environmental strains from epidemic strains and the variations between invasive and non-invasive infections. Other projects involve investigating the evolutionary history of deep-branching protists as well as how other intestinal bacteria are linked to intestinal disorders.
What’s the best part of your day?
"All of us are the result of successful survival and reproduction in an unbroken chain leading right back to bacteria and the origin of all life."
What’s your proudest work achievement so far? Is there something you would have done differently?
I’m fairly early in my career so my proudest moment was passing my
What would be your ideal research project?
My ideal research project would be a metagenomic project investigating the interactions between the human, bacterial, protist and viral components of the intestinal microbiome. Traditionally, in this type of investigation, the first thing you do is take an organism of interest out of the gut environment and study it in isolation, thereby losing all of the information about how it's actually behaving in its natural environment. More and more, it looks as though the answer to these questions revolves around the interplay between the organism of interest and all the other things floating around in your guts. We are only now developing technology advanced enough to make projects like this feasible.
What has been your biggest challenge?
During my undergraduate degree, I spent a year working as a research technician in a lab in Chicago. That was a baptism of fire for working in science. Not only did I get first-hand, hands-on experience of working in a real research lab, but I also had to cope with being in a different country. Little things, like buying toothpaste became a challenge; do you go to Trader Joes? Or Target? Or Walgreens? On the plus side, I was introduced to spray-on cheese and Potbelly (google it)!
Ross on his very nice computer.
Who or what inspires you?
I take my inspiration from our own evolutionary history as self-indulgent as that sounds. All of us is the result of successful survival and reproduction in an unbroken chain leading back - past your parents and grandparents, past the common ancestor we share with chimps, past our common ancestors with other animals, insects, plants - right back to bacteria and on to the origin of all life. One unbroken chain.
What do you like to do out of work?
When I’m not at work, I like to relax by playing computer games (I’m a PlayStation man all the way), but when I need time not looking at a screen, I’m also a qualified
The Jiu-Jitsu Master in action.
What are your career aspirations; where would you like to be in five-years’ time?
My dream is to prove something in a text book wrong. Something innocuous that everyone takes for granted because that’s where the fame and fortune lies. But in five years, I’ll settle for coming to the end of my second or third postdoc and looking to advance my career by founding my own research group.
What advice would you give to those who are interested in getting into genomics research?
Learn how to code. Perl,