- Research group
Leggett Group
Developing algorithms to enable new technologies.
Group Leader
Richard Leggett
Group activities.
The Technology Algorithms Group is focused primarily on two areas:
- Evaluating new genomics technologies and developing bioinformatics enabling tools.
- Algorithms for analysis and assembly of metagenomic data - often inspired by new technology developments.
A lot of our current work involves third generation sequencing platforms (Oxford Nanopore, PacBio), but we are also evaluating new protocols and developing new tools for short read technologies (e.g. 10x).
Some of our current projects include:
- Development of the NanoOK tool for nanopore data analysis
- Development of MetaCortex, an assembly tool for metagenomic data
- In-field and real-time sequencing
- Clinical and environmental sequencing projects
- Ocean metagenomics
- Viral metagenomics
- Real-time, low-power, efficient analysis
- Optical computing
Team members.
Visiting and affiliated colleagues.
Tools.
NextClip
A tool for comprehensive quality analysis and read preparation for Nextera long mate pair (LMP) libraries.
NanoOK
A tool for comprehensive analysis of Oxford Nanopore MinION sequence data.
Kontaminant
Kmer-based screening of sequencing data.
Bubbleparse
Identification of SNPs from sequencing data without a reference.
Publications.
Identifying and Classifying Trait Linked Polymorphisms in Non-Reference Species by Walking Coloured de Bruijn Graphs
Leggett R.M., Ramirez-Gonzalez R.H., Verweij W., Kawashima C.G., Iqbal Z., Jones J.D.G., Caccamo M., MacLean D. (2013).
PLoS ONE 8(3): e60058.
