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National Capabilities.

Enabling expert provision of resources and services throughout genomics, synthetic biology, high performance computing and scientific training.

The Earlham Institute is a hub of modern life science research. Our state-of-the-art building is home to exceptional scientists and cutting-edge facilities, creating a unique combination of expertise and infrastructure. We are proud to host four UKRI-BBSRC National Capabilities, which provide the UK bioscience community access to our tools, technology, and the talented individuals you need to answer key biological questions and deliver impact.

The Earlham Institute is home to dedicated laboratories for genome sequencing, single-cell analysis, engineering biology, and large-scale automation. The Institute also hosts one of the largest supercomputing facilities for life science research in Europe, which supports the UK research community with open source computational resources and e-Infrastructure platforms, such as CyVerse UK.

To maximise the impact of our facilities and platforms, our scientific training programme works alongside each of the National Capabilities to deliver expert-led courses. This allows us to maintain a world-class talent pool of researchers who ensure the UK continues to drive forward advances across the spectrum of life science research.


 

Our National Capabilities.

Earlham Institute has become recognised as a leading institute in the spheres of genomics, bioinformatics, engineering biology, e-Infrastructure, high-performance computing and scientific training.

As such, supported through BBSRC funding, our National Capabilities (NC) cover four major programmes:

  • Genomics and Single Cell Analysis
  • Earlham Biofoundry
  • e-Infrastructure
  • Advanced Scientific Training

The National Capability in Genomics and Single-Cell provides multi-omic and single-cell services to a worldwide network of researchers and an interface to EI’s research outputs. Low-cost, in-house pipelines enable characterisation of biological repositories and monitoring of plant pathogens.

  • A new focus on a priority area of single-cell genomics and analysis
  • Supports agri-science and bioscience for health
  • Expertise in non-model organisms and complex genomes
  • CSPro, CSP, Reference Site
  • Dedicated multidisciplinary staff
  • International user base
  • Demonstrable background in characterising emerging plant pathogens

The Plant and Microbe BIO Foundry builds and transforms synthetic constructs into plants, algae and microbes. An OpenMTA parts repository and online registry engages users. Leading a consortium of UK foundries and linking other core facilities provides ‘whole-experiment’ design.

  • Focus on plants and microbes
  • Supporting agri-science, exploiting new ways of working, industrial biotechnology
  • Infrastructure and scientific leads in place
  • Shares project management & automation specialists with the National Capability in Genomics and Single-Cell
  • Links to BIO Foundry LIMS

Delivering resources and personnel for:

  • Large genome assembly, with the largest shared-memory HPC system for the life sciences in the UK
  • Cyverse-UK, an ELIXIR-UK hosting platform, which is the first federated node outside of the USA for this $100M NSF project
  • UK-SeeD, which allows UK and CIMMYT researchers to collaborate on data intensive research projects
  • SignaLink, an ELIXIR-UK roadmap resource, which allows visualisation and analysis of pathway regulation in model organisms across 50 data sources

Delivering training programmes and best practice for early-career researchers to enable multi-disciplinary scientists and address skills gaps. Training from international and EI researchers delivers strategically relevant, practical courses aligned with Earlham’s science.

  • Led by a multidisciplinary team with the ability to address skills shortages
  • Targeted ’wet and dry’ training for early career researchers with international and EI experts
  • Hands on training in real-world data analysis enables wider utility of National Capability offerings
  • Linked to European training activities as part of ELIXIR and contribute to globally shared training materials via GOBLET etc